Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses
Authors' conclusion
Gut microbial composition in patients with established RA is different from that in healthy individuals.
Study context
- Population
- Patients with established rheumatoid arthritis (RA) managed long-term with disease-modifying anti-rheumatic drugs (DMARDs), and healthy participants
- Participants
- 94 vs 30
- Exposure
- Established RA vs healthy participants
- RAn = 94
- Healthyn = 30reference
- Outcome
- Gut microbiota composition and factors associated with it; prediction of response to csDMARDs
Methodological details16S rRNA amplicon sequencing, prospective follow-up of treatment response at 6 months
- 16S rRNA amplicon sequencing
- Prospective follow-up of treatment response at 6 months
Main finding
As reported in the abstract
Gut microbiota composition
- Gut microbiota composition in established RA different from healthy participants
- Young RA (< 45 years): reduced richness, evenness and distinct composition vs older RA and healthy individuals
- Disease activity and RF levels not associated with microbiome composition
- bDMARDs and csDMARDs, except sulfasalazine and TNF inhibitors respectively, not associated with gut microbial composition
Observational data: associations, not effects.
Further findings
Prediction of response to second-line csDMARDs in insufficient responders to first-line csDMARDs · 6 months
- Combination of Subdoligranulum and Fusicatenibacter genera associated with future good response to second-line csDMARDs
Original publication
Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses. Arthritis Res Ther. Published 2 March 2023. doi:10.
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