Rheumatoid Arthritis Disease Activity and Hospitalized Infection in a Large US Registry
Authors' conclusion
The risk of hospitalized infection was higher for patients with RA in low or moderate disease activity than for those in remission after accounting for the interplay of disease activity, RA treatments, treatment switching, and other potential confounders.
Study context
- Population
- Patients with rheumatoid arthritis (RA) in the CorEvitas registry with Medicare coverage, 2006–2019, with at least 1 visit with moderate disease activity (Clinical Disease Activity Index (CDAI) >10 and ≤22)529 hospitalized infections
- Participants
- 3,254 patients
- Exposure
- Low or moderate disease activity vs remission
- Outcome
- Hospitalized infection (linked Medicare data)
Methodological detailsregistry-based, linked Medicare data, marginal structural models, time-varying exposure
- Registry-based
- Linked Medicare data
- Marginal structural models
- Time-varying exposure
Main finding
As reported in the abstract
Hospitalized infection (marginal structural models (MSMs))
Each group vs remissionHazard ratio (95% CI)
Low disease activity
1.60(1.13–2.28)
Moderate disease activity
1.83(1.30–2.64)
Observational data: associations, not effects.
Original publication
Rheumatoid Arthritis Disease Activity and Hospitalized Infection in a Large US Registry. Arthritis Care Res (Hoboken). Published 2 March 2023. doi:10.
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