Factors associated with suicidal ideation among patients with inflammatory rheumatic and musculoskeletal diseases: A case-control study
Authors' conclusion
A substantial number of patients reported suicidal ideation. Cases were identified by factors associated with suicide in the general population whereas disease-specific factors did not differentiate between cases and controls. Short disease duration, the presence of a somatoform syndrome, higher impulsivity, and neuroticism were associated with suicidal ideation.
Study context
- Population
- Patients with inflammatory rheumatic and musculoskeletal diseases (iRMD) in an observational cohort50 cases and 150 controls participated
- Participants
- 2,960 patients
- Comparison
- iRMD patients with suicidal ideation (cases) vs matched iRMD patients without suicidal ideation (controls)
- Casesn = 50
- Controlsn = 150reference
- Outcome
- Prevalence of suicidal ideation and factors associated with suicidal ideation
Methodological detailsage, gender and disease-matched (1:3), nested in an observational cohort, logistic regression analysis, Standardized clinical interview by a psychosomatic expert in cases
- Age, gender and disease-matched (1:3)
- Nested in an observational cohort
- Logistic regression analysis
- Standardized clinical interview by a psychosomatic expert in cases
Main finding
As reported in the abstract
iRMD patients with suicidal ideation
95
3.2%
Observational data: associations, not effects.
Further findings
Patient-reported outcomes, disease severity, life satisfaction, optimism, abuse history, help- and hopelessness
- PRO and disease severity substantially higher in cases vs controls
- Cases less satisfied with their lives and less optimistic than controls
- History of abuse and feelings of help- and hopelessness more often in cases
- Psychiatric disorders more often in cases than controls
Most frequent psychiatric disorders in cases
- Affective disorders
- 80%
- Somatic stress disorders
- 64%
- Trauma-related disorders
- 36%
Original publication
Factors associated with suicidal ideation among patients with inflammatory rheumatic and musculoskeletal diseases: A case-control study. Joint Bone Spine. Published 10 February 2026. doi:10.
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