Expression of CD163 and major histocompatibility complex class I as diagnostic markers for idiopathic inflammatory myopathies
Authors' conclusion
Combination of CD163 and MHC class I muscular expression may be useful in diagnosing IIMs.
Study context
- Population
- Muscle biopsy tissues from IIM patients meeting 2017 EULAR/ACR criteria and controls with non-inflammatory myopathies or healthy muscle
- Comparison
- Algorithm combining CD163 and MHC class I muscular expression vs IIM-related histopathologic features for diagnosing IIM
- IIMn = 129
- Controln = 73reference
- Outcome
- Diagnostic ability for IIM of an inflammation-related immunohistochemistry marker-based algorithm
Methodological detailsclassification and regression tree (CART) analysis
- Classification and regression tree (CART) analysis
Performance
As reported in the abstract
Diagnostic performance for IIM
| Test or model | Sensitivity | Specificity | Accuracy |
|---|---|---|---|
| CD163 + MHC class I algorithm | 96.1% | 94.5% | 95.5% |
| IIM-related histopathologic features | 80.6% | 100.0% | 87.6% |
Sensitivity
CD163 + MHC class I algorithm96.1%
IIM-related histopathologic features80.6%
Specificity
CD163 + MHC class I algorithm94.5%
IIM-related histopathologic features100.0%
Accuracy
CD163 + MHC class I algorithm95.5%
IIM-related histopathologic features87.6%
Further findings
| Outcome | IIM | Control | P value |
|---|---|---|---|
| Muscular CD163 expressionIIM vs Control | 99.2% | 20.8% | P < 0.001 |
| Muscular MHC class I expressionIIM vs Control | 87.6% | 23.1% | P < 0.001 |
Correct IIM diagnosis by the algorithm in patients not meeting 2017 EULAR/ACR criteria but diagnosed with IIM by an expert physician (subgroup)
- Algorithm correctly diagnosed IIM
- 94.1% (16/17)
Original publication
Expression of CD163 and major histocompatibility complex class I as diagnostic markers for idiopathic inflammatory myopathies. Arthritis Res Ther. Published 30 July 2024. doi:10.
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