Autoinflammatory & rare systemic diseases
Exposure during pregnancy to Il-1 targeted therapies and pregnancy, foetal and neonatal outcomes: a study from the French Teratology Information Service
Authors' conclusion
In this study, the largest series to date, our results do not suggest occurrence of specific negative outcomes in pregnancies exposed to anti-IL-1.
Study context
- Population
- Pregnancies exposed to anti-IL-1 (anakinra and/or canakinumab) with known outcomes, referred to CRAT 2007–2023; 27 (47.3%) treated for Still's disease
- Participants
- 57 pregnant women
- Exposure
- Anakinra vs Canakinumab vs Both medications
- Anakinran = 43
- Canakinumabn = 5
- Both medicationsn = 4
- Outcome
- Pregnancy, foetal and neonatal outcomes
Methodological detailsprospective and retrospective pregnancies, French Teratology Information Service (CRAT) data
- Prospective and retrospective pregnancies
- French Teratology Information Service (CRAT) data
Main finding
As reported in the abstract
| Group | Value | Exposed during T1 | Exposed during all pregnancy | Early miscarriages | Medical abortion | Elective abortion | Major congenital malformation prevalence among T1-exposed | Malformations |
|---|---|---|---|---|---|---|---|---|
| Anakinra | 85.1% | 40/47 (85.1%) | 21/47 (44.7%) | 5/47 (10.6%) | 1 | 1 | 3.03% IC 95% [0.1-15.1] | |
| Canakinumab | 9/9 events | 9/9 | 2/9 | 0 |
Value
Anakinra85.1%
Canakinumab9/9 events
Exposed during T1
Anakinra40/47 (85.1%)
Canakinumab9/9
Exposed during all pregnancy
Anakinra21/47 (44.7%)
Canakinumab2/9
Early miscarriages
Anakinra5/47 (10.6%)
Canakinumab— not stated in the abstract
Medical abortion
Anakinra1
Canakinumab— not stated in the abstract
Elective abortion
Anakinra1
Canakinumab— not stated in the abstract
Major congenital malformation prevalence among T1-exposed
Anakinra3.03% IC 95% [0.1-15.1]
Canakinumab— not stated in the abstract
Malformations
Anakinra— not stated in the abstract
Canakinumab0
- Anakinra: one isolated hypospadias (anakinra between 0 and 4 weeks of gestation)
- 1
Observational data: associations, not effects.
Further findings
- Retrospective pregnancies (anakinra)
- 6/6 · events
- Retrospective pregnancies (anakinra) — All resulted in live births; cardiopathy with hypospadias in a child with a rare genetic anomaly
- 1
Safety
- No significant effects reported while breastfeeding (n = 9)
Original publication
Exposure during pregnancy to Il-1 targeted therapies and pregnancy, foetal and neonatal outcomes: a study from the French Teratology Information Service. Rheumatology (Oxford). Published 12 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →