Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective
Authors' conclusion
The study findings suggest that anti-MAP antibodies are more prevalent in RA patients compared to healthy controls, potentially implicating MAP in the development of RA.
Study context
- Population
- Outpatient attendees at a rheumatology specialist's clinic with Rheumatoid Arthritis (RA) (2010 ACR/EULAR criteria) and healthy controls
- Participants
- 119 vs 120
- Comparison
- RA vs healthy controls
- RAn = 119
- Healthy controls (HCs)n = 120reference
- Outcome
- Serum antibodies against MAP_402718-32 and IRF5424-434 peptides (indirect ELISA)
Methodological detailsindirect enzyme-linked immunosorbent assay (ELISA)
- Indirect ELISA
Main finding
As reported in the abstract
Anti-MAP_402718-32 antibodies
Observational data: associations, not effects.
Further findings
Anti-IRF5424-434 antibodies
- Anti-MAP_402718-32 antibodies among RA patients, treatment vs no-treatment (subgroup): Treatment 51.6%
- Anti-MAP_402718-32 antibodies among RA patients, treatment vs no-treatment (subgroup): No-treatment 36.4%
Anti-IRF5424-434 antibodies
- Difference statistically significant
Anti-MAP_402718-32 antibodies among RA patients, treatment vs no-treatment (subgroup)
- Difference not statistically significant
Correlation between IRF5424-434 and MAP_402718-32 homolog
- Moderate correlation
Original publication
Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective. Arthritis Res Ther. Published 21 February 2025. doi:10.
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