Vasculitis & polymyalgia rheumatica
Exploration of health-related quality of life, anxiety and depression in antineutrophil cytoplasmic antibody-associated vasculitis
Authors' conclusion
In patients with AAV, HRQoL, anxiety, depression and fatigue are persistent but vary depending on disease activity, disease duration, gender and age.
Study context
- Population
- Persons with ANCA-associated vasculitis (AAV)
- Outcome
- HRQoL (EQ-5D-3L, EQ-VAS), anxiety and depression (HADS) and fatigue (MAF)
Main finding
As reported in the abstract
HRQoL, anxiety, depression and fatigue
- EQ-VAS health-related quality of life (HRQoL) higher in younger patients, those with inactive disease (BVAS = 0) and those with long disease duration (≥3 years); EQ-5D-3L varied only with disease activity
- Women, patients with active disease and patients with shorter disease duration reported more anxiety
- Younger persons with active disease and short disease duration reported more fatigue
- In the total group, disease activity and disease duration both associated with HRQoL, anxiety, depression and fatigue
- Four clusters based on EQ-5D, EQ-5D index and Hospital Anxiety and Depression Score (HADS) identified, with various levels of HRQoL and psychological distress across the disease course
Observational data: associations, not effects.
Original publication
Exploration of health-related quality of life, anxiety and depression in antineutrophil cytoplasmic antibody-associated vasculitis. Rheumatology (Oxford). Published 8 August 2025. doi:10.
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