Exercise and the prevention of major osteoporotic fractures in adults: a systematic review and meta-analysis with special emphasis on intensity progression and study duration
Pooled result · Major osteoporotic fracturesResult — go to the resultRelative risk 0.75 95% CI 0.54–0.94Authors' conclusion
The present systematic review and meta-analysis provided significant evidence for the favorable effect of exercise on major osteoporotic fractures.
Study context
- Population
- Adults in controlled exercise studies reporting low-trauma major osteoporotic fractures separately for exercise and control groups11 studies
- Comparison
- Exercise vs control
- Outcome
- Incidence ratio (IR) for major osteoporotic fractures
Methodological detailsPRISMA guideline, six literature databases, mixed-effects conditional Poisson regression
- PRISMA guideline
- Six literature databases
- Mixed-effects conditional Poisson regression
Pooled result
Major osteoporotic fractures
Relative risk
0.75
95% CI 0.54–0.94
P = 0.006
EGvs CG
RR 0.75 (95% CI 0.54–0.94); P = 0.006
As reported in the abstract
Further pooled results
Major osteoporotic fractures by intensity progression (yes vs no) (subgroup)
- No significant difference for diverging intensity progression, although studies with intensity progression were more favorable
- P = 0.133
Major osteoporotic fractures by study duration (≤ 12 months vs > 12 months) (subgroup)
- No significant difference for study duration
- P = 0.883
Heterogeneity among trials of the subgroups
- I2 (negligible)
- ≤ 0-7.1%
Original publication
Exercise and the prevention of major osteoporotic fractures in adults: a systematic review and meta-analysis with special emphasis on intensity progression and study duration. Osteoporos Int. Published 10 November 2022. doi:10.
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