Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto’s thyroiditis
Authors' conclusion
The results demonstrate an increased incidence of HT in cSLE patients, even if they are euthyroid
Study context
- Population
- Patients with childhood-onset SLE (cSLE)
- Participants
- 73 cSLE patients
- Exposure
- cSLE patients vs healthy controls
- cSLEn = 73
- Outcome
- Prevalence and contributing factors of thyroid dysfunction and Hashimoto's thyroiditis (HT)
Methodological detailshealthy control comparison
- Healthy control comparison
Main finding
As reported in the abstract
| Group | Value | Subclinical hypothyroidism | Clinical hypothyroidism | Hashimoto's thyroiditis (HT) | Family history of HT |
|---|---|---|---|---|---|
| cSLE | 19.1% | 14 (19.1%) | 9 (12.3%) | 12 (16.4%) | 12 (16.4%) |
cSLE
Value19.1%
Subclinical hypothyroidism14 (19.1%)
Clinical hypothyroidism9 (12.3%)
Hashimoto's thyroiditis (HT)12 (16.4%)
Family history of HT12 (16.4%)
Observational data: associations, not effects.
Further findings
Factors associated with HT (HT vs no HT within cSLE)
- No significant differences in clinical and laboratory data or medication used
- Higher frequency of clinical hypothyroidism and family history of HT in patients with HT
- Cumulative prednisolone dose significantly lower in patients with HT
Thyroid US in 5 euthyroid and 1 borderline subclinical hypothyroid patient with positive thyroid autoantibody
- Diffuse heterogeneous echogenicity enlargement in the thyroid gland
Original publication
Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto’s thyroiditis. Lupus. Published 9 August 2024. doi:10.
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