Spondyloarthritis & psoriatic arthritis
Evaluating the impact of the ASAS early axial spondyloarthritis definition on radiographic progression over 12years
Authors' conclusion
The findings suggest that the ASAS definition criteria for early stage do not significantly influence long-term radiographic outcomes in axSpA.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in the Korean spondyloarthropathy registry
- Participants
- 445 patients
- Exposure
- Early axSpA vs established axSpA
- Outcome
- Radiographic progression: annual changes in mSASSS
- Follow-up
- 12 years
Methodological detailsregistry-based, observational, Two radiologists independently scored the radiographs
- Registry-based
- Observational
- Two radiologists independently scored the radiographs
Main finding
As reported in the abstract
mSASSS changes (intervals 0-4, 0-6, 0-8, 0-10, 0-12 years)
- No statistically significant differences in Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) changes between early and established axSpA, regardless of TNF-α blocker inclusion
- Univariable and multivariable analyses: no effect of early axSpA status on mSASSS changes
- Adjusted for pertinent covariates (linear regression)
Observational data: associations, not effects.
Original publication
Evaluating the impact of the ASAS early axial spondyloarthritis definition on radiographic progression over 12years. Joint Bone Spine. Published 23 July 2025. doi:10.
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