Evaluating CA-125 and PET/CT for cancer detection in idiopathic inflammatory myopathies
Authors' conclusion
False-positive and false-negative results are prevalent in cancer antigen 125 (CA-125) and PET/CT testing for adult patients with newly diagnosed idiopathic inflammatory myopathy.
Study context
- Population
- Adult idiopathic inflammatory myopathy (IIM) patients, single centre, enrolled 2003 to 2020IIM cohort
- Participants
- 1,432 patients
- Comparison
- CA-125 vs PET/CT for cancer detection
- CA-125n = 205
- PET/CTn = 139
- Outcome
- True-positive, false-positive, true-negative and false-negative results for cancer detection
- Follow-up
- Within five years of IIM symptom onset
Methodological detailsretrospective, single-centre cohort
- Retrospective
- Single-centre cohort
Performance
As reported in the abstract
Diagnostic accuracy for cancer · within first five years of symptom onset
False-positive rate
False-negative rate
| Outcome | CA-125 | PET/CT |
|---|---|---|
| Tests | 250 | 149 |
Original publication
Evaluating CA-125 and PET/CT for cancer detection in idiopathic inflammatory myopathies. Rheumatology (Oxford). Published 2 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →