Lupus & antiphospholipid syndrome
Epidemiology of SLE in Italy: an observational study using a primary care database
Authors' conclusion
The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years.
Study context
- Population
- People in The Health Improvement Network general practice database in Italy, 2017–2022
- Participants
- 634,753 people
- Outcome
- Incidence and prevalence of SLE
- Follow-up
- 2022
Methodological detailsprimary care database (THIN Italy), three alternative case definitions
- Primary care database (THIN Italy)
- Three alternative case definitions
Main finding
As reported in the abstract
Incidence rate, cases per 100 000 person-years
6.51
95% CI 6.29 to 6.74
Prevalence per 100 000 people
60.57
95% CI 59.89 to 61.25
Incident cases 2017-2022
191
Prevalent cases 2017-2022
1385
Observational data: associations, not effects.
Further findings
Trends and variation
- Both estimates trended upwards since 2017
- Geographical variation across the country
- Potential associations of SLE incidence with pre-existing CKD, chronic hepatic disease, RA and Sjogren's syndrome
Original publication
Epidemiology of SLE in Italy: an observational study using a primary care database. Lupus Sci Med. Published 13 May 2024. doi:10.
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