Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials
Pooled result · Function scoreResult — go to the resultMD −6.46 95% CI −9.52 to −3.40Authors' conclusion
The results of this meta-analysis suggest that oral collagen administration relieves OA symptoms.
Study context
- Population
- Patients with knee osteoarthritis (OA) in randomised controlled trials (RCTs) (searches to October 2023)
- Participants
- 870 patients11 RCTs
- Comparison
- Oral collagen-based supplements vs placebo
- Collagen supplementationn = 451
- Placebon = 419reference
- Outcome
- Clinical efficacy on knee OA symptoms (function and pain scores)
Methodological detailsrandom- or fixed-effects model, generic inverse variance method, Cochrane Risk of Bias 2.0
- Random- or fixed-effects model
- Generic inverse variance method
- Cochrane Risk of Bias 2.0
Pooled result
Function score
MD
−6.46
95% CI −9.52 to −3.40
P = 0.00001
Collagen supplementationvs Placebo
MD −6.46 (95% CI −9.52 to −3.40); P = 0.00001
As reported in the abstract
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Pain scoreI2=88% | −13.63 (−20.67 to −6.58) | P = 0.00001 | |
| −30−20−10010Difference (linear scale) |
Original publication
Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. Published 5 March 2024. doi:10.
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