Dynamic change in red cell distribution width as a predictor for short-time mortality in dermatomyositis-associated rapid progressive interstitial lung disease
Main finding · Prognosis in IIM-ILD (RDW as independent risk factor)Result — go to the resultHazard ratio 2.9Authors' conclusion
These findings suggest that repeated RDW assays could assist physicians in identifying patients with DM-ILD who were at a high risk of RP-ILD and death.
Study context
- Population
- Patients with idiopathic inflammatory myopathies (IIM) and naïve ILD with complete medical records, 2009–2021of 1822 IIM patients evaluated
- Participants
- 532 patients
- Exposure
- Elevated RDW vs normal RDW
- Outcome
- RP-ILD and poor short-term outcomes (mortality)
Methodological detailsconsecutive patients, average follow-up of 4 years
- Consecutive patients
- Average follow-up of 4 years
Main finding
As reported in the abstract
Prognosis in IIM-ILD (RDW as independent risk factor)
Hazard ratio
2.9
P = 0.03
Observational data: associations, not effects.
Further findings
Prevalence of ∆RDW-3>0 in RP-ILD, anti-MDA5-positive: died within 3 months vs alive at 3 months
P < 0.001
- ILD prevalence · higher with elevated RDW
- P < 0.001
- PaO2/FiO2, FVC% and DLco% (lower) and rapidly progressive interstitial lung disease (RP-ILD) prevalence (higher) in ILD with elevated RDW
- P < 0.001
Death within 3 months in dermatomyositis (DM) with RP-ILD
- ∆RDW-3 greater than 0 more likely to die within 3 months
Original publication
Dynamic change in red cell distribution width as a predictor for short-time mortality in dermatomyositis-associated rapid progressive interstitial lung disease. RMD Open. Published 5 April 2024. doi:10.
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