Dual-energy CT for evaluating bone marrow oedema in rheumatoid arthritis (RA): an observational single-center study
Authors' conclusion
DECT images demonstrated excellent diagnostic performance in identifying the extent of BME and could serve as a potential evaluative instrument for disease activity in RA patients.
Study context
- Population
- RA patients who underwent both Dual-energy CT (DECT) and 3.0-T magnetic resonance imaging (MRI)
- Participants
- 63 patients
- Comparison
- DECT vs 3.0-T MRI for BME
- Outcome
- Accuracy of DECT for BME diagnosis (ROC analysis), MRI as reference
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Performance
As reported in the abstract
Detection of BME in wrist and MCP joints
| Test or model | AUROC | Sensitivity | Specificity | False-positive | False-negative | PPV | NPV |
|---|---|---|---|---|---|---|---|
| DECT | 0.927 | 97.2% | 88.2% | 11.8% | 2.8% | 98.2% | 83.3% |
DECT
AUROC0.927
Sensitivity97.2%
Specificity88.2%
False-positive11.8%
False-negative2.8%
PPV98.2%
NPV83.3%
Further findings
Correlation of DECT scores with disease activity
- Positive correlations of DECT BME score with ESR and CRP, and of DECT total score with ESR, CRP and DAS28-ESR
- P < 0.00625
Original publication
Dual-energy CT for evaluating bone marrow oedema in RA: an observational single-center study. Rheumatology (Oxford). Published 2 April 2025. doi:10.
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