Dual dynamics of persistence and recruitment characterise the ACPA-expressing B cell response in rheumatoid arthritis
Authors' conclusion
These observations demonstrate that the ACPA-expressing B cell population includes persistent and newly recruited cells that together fuel this ongoing autoimmune response.
Study context
- Population
- Patients with RA; ACPA-expressing B cells1,581 BCR sequences
- Outcome
- ACPA-expressing B cell repertoire dynamics
Methodological detailslongitudinal, ACPA-expressing B cells isolated by tetramer-based flow cytometry, BCR sequencing by Smart-Seq2-based immunoglobulin-gene amplification and paired heavy/light-chain Sanger sequencing, antigen reactivity validated by producing and testing monoclonal antibodies
- Longitudinal
- ACPA-expressing B cells isolated by tetramer-based flow cytometry
- BCR sequencing by Smart-Seq2-based immunoglobulin-gene amplification and paired heavy/light-chain Sanger sequencing
- Antigen reactivity validated by producing and testing monoclonal antibodies
Main finding
As reported in the abstract
Multiple clonal families traced over time
8 years
Original publication
Dual dynamics of persistence and recruitment characterise the ACPA-expressing B cell response in rheumatoid arthritis. Ann Rheum Dis. Published 29 April 2026. doi:10.
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