Cognitive impairment risk in patients with rheumatoid arthritis: a population-based cohort study
Main finding · Incident cognitive impairmentResult — go to the resultAdjusted subdistribution hazard ratio 1.222 95% CI 1.171–1.275Authors' conclusion
These findings suggest that cognitive impairment may represent an important comorbidity in patients with RA
Study context
- Population
- Patients newly diagnosed with rheumatoid arthritis (RA) (2011–2014) and matched controls, Korean nationwide claims database; follow-up to December 2022matched cohort
- Participants
- 26,437 vs 26,437
- Exposure
- Newly diagnosed RA vs matched controls
- RAn = 26,437
- Controlsn = 26,437reference
- Outcome
- Incident cognitive impairment (ICD-10 F00-F03, F31.82, F06.7, G30 and G31.00)
Methodological details1:1 age-, sex- and index-year-matched, Korean nationwide claims database, multivariable stratified competing risks regression (death as competing risk)
- 1:1 age-, sex- and index-year-matched
- Korean nationwide claims database
- Multivariable stratified competing risks regression (death as competing risk)
Main finding
Incident cognitive impairment · mean follow-up 9.410±2.271 (RA) and 9.508±2.217 (Controls) years
Adjusted subdistribution hazard ratio
1.222
95% CI 1.171–1.275
Events by group
RAvs Controls
adjusted SHR 1.222 (95% CI 1.171–1.275)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Cognitive impairment risk in patients with rheumatoid arthritis: a population-based cohort study. RMD Open. Published 28 April 2026. doi:10.
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