Do subjective components of disease activity contribute to heterogeneity in opioid prescriptions in inflammatory rheumatic diseases? Results from ESPOIR and DESIR cohorts
Authors' conclusion
Non-inflammatory pain mechanisms amplify subjective outcomes, thus, worsening composite measures like disease activity.
Study context
- Population
- Early inflammatory rheumatic diseases: Rheumatoid arthritis (RA) (ESPOIR) and spondyloarthritis (SpA) (DESIR), followed 10 and 6 years810 RA, 679 SpA
- Exposure
- Opioid-prescription trajectories vs no/low trajectory
- Outcome
- Evolution of disease activity (DAS28 for RA; ASDAS-CRP for SpA) and its subjective components by opioid-prescription trajectory
Methodological detailstwo prospective observational cohorts (ESPOIR, DESIR), group-based trajectory modelling, mixed models
- Two prospective observational cohorts (ESPOIR, DESIR)
- Group-based trajectory modelling
- Mixed models
Main finding
As reported in the abstract
Disease activity vs no/low trajectory (β) · throughout follow-up
- Persistent
- β DAS28 0.4-0.8
- Persistent
- β axial spondyloarthritis disease activity score-C-reactive protein (ASDAS-CRP) 0.4-0.6
- Augmenting
- β DAS28 0.2-0.5
- Augmenting
- β ASDAS-CRP 0.3-0.6
- Declining · until 3- or 4-years of follow-up
- β DAS28 0.3-0.4
- Declining · until 3- or 4-years of follow-up
- β ASDAS-CRP 0.2-0.3
Observational data: associations, not effects.
Further findings
- Prescribed opioids at least once
- 60%
- Regular opioid prescriptions: often older, less educated, higher BMI, worse disease
- up to 30%
Original publication
Do subjective components of disease activity contribute to heterogeneity in opioid prescriptions in inflammatory rheumatic diseases? Results from ESPOIR and DESIR cohorts. Clin Exp Rheumatol. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →