Distinction and prognosis of early arthritis phenotypes: an analysis in three European cohorts
Authors' conclusion
Radiographic progression over time primarily occurs in EA patients with APR/autoantibodies. The absence of these markers, however, does not necessarily translate into better long-term function and quality of life.
Study context
- Population
- Patients with early arthritis in three European cohorts (Reade, ESPOIR, Early Arthritis Clinic (EAC)), clinical data up to 24 yearsReade 390, ESPOIR 798, EAC 3991
- Exposure
- Early arthritis (EA) phenotypes at baseline compared for long-term prognosis
- Outcome
- Long-term prognosis: HAQ, SF36 and SvdH score over time
- Follow-up
- Up to 24 years
Methodological detailsthree European early arthritis cohorts (Reade, ESPOIR, EAC), latent class analysis, multivariable models
- Three European early arthritis cohorts (Reade, ESPOIR, EAC)
- Latent class analysis
- Multivariable models
Main finding
As reported in the abstract
Long-term prognosis by EA phenotype
- Sharp van der Heijde (SvdH) scores worse in autoimmune inflammatory polyarthritis (AIPA) (acute phase reactants (APR)/autoantibodies) than in MIPA
- No clinically meaningful differences across classes in Health Assessment Questionnaire (HAQ) or SF36 over time
Observational data: associations, not effects.
Original publication
Distinction and prognosis of early arthritis phenotypes: an analysis in three European cohorts. RMD Open. Published 1 November 2023. doi:10.
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