Distinct periarticular muscle transcriptomes: inflammation in rheumatoid arthritis versus metabolic dysregulation in osteoarthritis
Authors' conclusion
This study reveals distinct molecular pathologies in the periarticular muscle of RA and OA. RA muscle shows an intense inflammatory profile potentially linked to cachexia, whereas OA muscle displays features of metabolic disease and pro-fibrotic remodelling.
Study context
- Population
- Patients with rheumatoid arthritis (RA) or osteoarthritis (OA) undergoing total joint arthroplasty; periarticular skeletal muscle samples
- Participants
- 6 vs 4
- Comparison
- Periarticular muscle transcriptome in RA vs OA
- RAn = 6
- OAn = 4
- Outcome
- Transcriptomic profiles of periarticular muscle
Methodological detailsbulk RNA sequencing, WGCNA, pathway enrichment, gene set variation analysis
- Bulk RNA sequencing
- WGCNA
- Pathway enrichment
- Gene set variation analysis
Main finding
As reported in the abstract
Periarticular muscle transcriptome
RA: IL-2-STAT5 signalling pathway correlation with DAS28-ESR (r), p=0.019
0.94
Original publication
Distinct periarticular muscle transcriptomes: inflammation in rheumatoid arthritis versus metabolic dysregulation in osteoarthritis. Clin Exp Rheumatol. Published 25 October 2025. doi:10.
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