Lupus & antiphospholipid syndrome
Different Immunologic Profiles Are Associated With Distinct Clinical Phenotypes in Longitudinally Observed Patients With Systemic Lupus Erythematosus
Authors' conclusion
Cellular phenotyping of patients with SLE reveals several distinct immunologic profiles that may help to stratify patients with regard to prognosis and treatment.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) (flaring or clinically quiescent) and healthy controls; peripheral blood at baseline and 6- and 12-month follow-up
- Participants
- 16 / 25 / 46
- Exposure
- Immune profiles in SLE flare vs quiescent SLE vs healthy controls
- Healthy controlsn = 16reference
- Quiescent SLEn = 25
- SLE flaren = 46
- Outcome
- Immunologic profile (47 peripheral blood immune populations) associated with disease flares in SLE
Methodological detailslongitudinal, multiparameter flow cytometry, unsupervised clustering
- Longitudinal
- Multiparameter flow cytometry
- Unsupervised clustering
Main finding
As reported in the abstract
- Five clusters of patients identified, variably containing active and quiescent SLE, with distinct clinical phenotypes
- 5
Observational data: associations, not effects.
Original publication
Different Immunologic Profiles Are Associated With Distinct Clinical Phenotypes in Longitudinally Observed Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 27 February 2024. doi:10.
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