Lupus & antiphospholipid syndrome
Development and evaluation of a Register-Based Organ Damage Index in systemic lupus erythematosus: a nationwide, population-based study from Sweden
Authors' conclusion
Our novel RBODI accurately estimates SDI scores and describes long-term trends in damage accrual in the largest cohort of incident SLE to date.
Study context
- Population
- Patients with SLE in Sweden: 271 prevalent cases (evaluation cohort) and newly diagnosed patients (2005–2021)evaluation cohort
- Participants
- 271 patients
- Comparison
- Register-Based Organ Damage Index (RBODI) vs SDI
- Outcome
- Accuracy of RBODI in estimating SLICC/ACR DI (SDI) scores
Methodological detailsnationwide, register-based
- Nationwide
- Register-based
Performance
As reported in the abstract
Accuracy of RBODI vs SDI
| Test or model | PPV | Sensitivity | Specificity |
|---|---|---|---|
| RBODI | 90% | 80% | 83% |
RBODI
PPV90%
Sensitivity80%
Specificity83%
Further findings
| Outcome | Values | HR |
|---|---|---|
| Organ damage within 5 years among newly diagnosed SLE (n = 4441) | Newly diagnosed SLE 40% | |
| First RBODI-based organ damage accrual by sexMales vs Females · 30% higher risk; adjusted | 1.3 | |
| First RBODI-based organ damage accrual by age>45 years old vs Younger · more than threefold higher risk; adjusted | 3.3 |
Mortality associated with RBODI-based organ damage within 5 years of diagnosis
- Early development of organ damage associated with higher risk of mortality
- 2.1-fold
Original publication
Development and evaluation of a Register-Based Organ Damage Index in systemic lupus erythematosus: a nationwide, population-based study from Sweden. Lupus Sci Med. Published 26 February 2025. doi:10.
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