Spondyloarthritis & psoriatic arthritis
Depression as a possible determinant of fatigue in patients with axial spondyloarthritis
Authors' conclusion
The study found correlation between fatigue and disease activity and depression in patients with axSpA.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA)
- Participants
- 119 patients
- Exposure
- Patients with fatigue vs without fatigue; depressed vs non-depressed
- Fatiguen = 53
- Outcome
- Prevalence of fatigue (CFQ) and its non-disease-related determinants, especially depression (HADS-D)
Methodological detailsunivariate and multivariate linear regression
- Univariate and multivariate linear regression
Main finding
As reported in the abstract
Prevalence of fatigue
Fatigue
44.5%
53
Observational data: associations, not effects.
Further findings
Scores in patients with vs without fatigue
- Patients with fatigue had higher HADS-D, Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Functional Index (BASFI), Health Assessment Questionnaire (HAQ) scores
HADS-D vs Chalder's Fatigue Questionnaire (CFQ) total in remission and moderate disease activity (subgroup)
- Correlation statistically significant also in patients in clinical remission and with moderate disease activity
CFQ in depressed vs non-depressed
- Depressed patients had higher CFQ score; no difference in CFQ scores when stratified for disease activity or systemic inflammation
Original publication
Depression as a possible determinant of fatigue in patients with axial spondyloarthritis. Clin Exp Rheumatol. Published 8 July 2023. doi:10.
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