Association between depression and anxiety and inability to achieve remission in rheumatoid arthritis and psoriatic arthritis
Authors' conclusion
The presence of depressive symptoms in RA and PsA patients at baseline or during follow-up was associated with a lower likelihood of achieving remission.
Study context
- Population
- RA and PsA patients from the tREACH and DEPAR; possible depression or anxiety disorder defined as Hospital Anxiety and Depression Scale (HADS) >7
- Participants
- 400 vs 367
- Exposure
- Possible depression or anxiety vs none, in RA and PsA
- RAn = 400
- PsAn = 367
- Outcome
- Remission (DAS44 <1.6 in RA; DAPSA ≤ 4 in PsA) during 2 years, by depression/anxiety at any timepoint
- Follow-up
- 2 years
Methodological detailsmixed models, 2 cohorts (tREACH, DEPAR)
- Mixed models
- 2 cohorts (tREACH, DEPAR)
Main finding
As reported in the abstract
Remission during 2 years of follow-up: depression vs no depression (adjusted for concurrent anxiety symptoms)
OR of achieving remission (95% CI)
Depression (RA)vs No depression (RA)RA; lower odds of achieving remission
0.45(0.25–0.80)
Depression (PsA)vs No depression (PsA)PsA; lower odds of achieving remission
0.24(0.08–0.71)
Observational data: associations, not effects.
Further findings
Possible depression and anxiety disorder at baseline
- RA, possible depression
- 20%
- RA, possible anxiety disorder
- 30%
- PsA, possible depression
- 18%
- PsA, possible anxiety disorder
- 23%
Disease activity components
- Depression/anxiety associated with higher tender joint count, worse general health, more pain and slightly elevated inflammation markers, but not with more swollen joints, in both RA and PsA
Original publication
Association between depression and anxiety and inability to achieve remission in rheumatoid arthritis and psoriatic arthritis. Rheumatology (Oxford). Published 6 November 2024. doi:10.
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