Lupus & antiphospholipid syndrome
Delayed onset of systemic lupus erythematosus in patients with idiopathic membranous nephropathy
Authors' conclusion
The diagnosis of membranous nephropathy does not entirely exclude the possibility of secondary nephropathy, even in patients with a high PLA2R antibody titer.
Study context
- Population
- Patients diagnosed with idiopathic membranous nephropathy at initial renal biopsy without extrarenal lupus manifestations who subsequently developed lupus nephritis (LN) or systemic lupus erythematosus (SLE) during follow-up, single centre, January 2017 to April 20245 female, 1 male
- Participants
- 6 patients
- Outcome
- Remission after immunotherapy, recurrence and progression to LN/SLE during follow-up in idiopathic membranous nephropathy (iMN) patients
- Follow-up
- 7.00 ± 5.21 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Remission after immunotherapy
6
Recurrence after follow-up
5
Repeat biopsy confirmed progression to LN (class Ⅲ+Ⅴ in two, class V in two)
4
Fulfilled 2019 EULAR/ACR SLE classification criteria
2
Observational data: associations, not effects.
Original publication
Delayed onset of systemic lupus erythematosus in patients with idiopathic membranous nephropathy. Lupus. Published 19 December 2025. doi:10.
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