Spondyloarthritis & psoriatic arthritis
Degenerative Disc Disease in Young Adults With Psoriatic Arthritis
Authors' conclusion
DDD is common in young patients with PsA, and its development may be associated with demographic features, comorbidities, and disease-related factors. IBP does not reliably distinguish between axial PsA and DDD.
Study context
- Population
- Patients with PsA aged < 50 years followed at a prospective observational cohort
- Participants
- 814 patients
- Outcome
- Prevalence of degenerative disc disease (DDD) on plain radiographs of the cervical and thoracolumbar spine
Methodological detailsprospective observational cohort, multivariate Cox regression, generalized estimating equations
- Prospective observational cohort
- Multivariate Cox regression
- Generalized estimating equations
Main finding
As reported in the abstract
Prevalence of DDD on plain spine radiographs
Patients with degenerative disc disease (DDD) on plain radiographs of the spine, of 814 included
316
38.8%
Observational data: associations, not effects.
Further findings
Factors associated with development of DDD (multivariate Cox regression)
| HR | P value | |
|---|---|---|
| Older age | 1.08 | P < 0.01 |
| Male sex | 1.52 | P = 0.03 |
| Diabetes mellitus | 2.35 | P = 0.045 |
| IBP | 2.03 | P < 0.01 |
- Being employed (vs unemployed), higher BMI, calcaneal spurs and targeted DMARD use showed a trending association with DDD
Association of imaging findings (isolated DDD, isolated axial disease, both) with type of back pain (GEE)
- None of the abnormal imaging findings significantly associated with back pain or inflammatory back pain (IBP)
Original publication
Degenerative Disc Disease in Young Adults With Psoriatic Arthritis. J Rheumatol. Published 15 February 2025. doi:10.
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