Definition of rheumatoid arthritis flare based on SDAI and CDAI
Authors' conclusion
We here provide novel definitions for flare in RA based on SDAI and CDAI, validated in two large independent real-world cohorts.
Study context
- Population
- Rheumatoid arthritis (RA) treatment courses from the Norwegian DMARD registry (NOR-DMARD) and the Vienna RA cohorttreatment courses
- Participants
- 4,256 vs 2,557
- Comparison
- NOR-DMARD vs Vienna RA
- NOR-DMARDn = 4,256
- Vienna RAn = 2,557
- Outcome
- Flare definitions for absolute changes in SDAI and CDAI based on a semiquantitative patient anchor
Methodological detailsROC analysis, 80% training / 20% test cohort, external validation
- ROC analysis
- 80% training / 20% test cohort
- External validation
Performance
As reported in the abstract
Preliminary flare definitions (absolute increase)
SDAI increase for flare
4.7
CDAI increase for flare
4.5
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Construct validity: change in HAQ, flare vs no flare | ∆ HAQ +0.43 | P < 0.001 |
| Construct validity: change in modified Sharp Score after flareFlare vs No flare | ∆ modified Sharp Score, % higher 43% | P < 0.001 |
Disease core sets
- Flares reflect consistent worsening across all disease core sets, patient reported and objective
Original publication
Definition of rheumatoid arthritis flare based on SDAI and CDAI. Ann Rheum Dis. Published 11 January 2024. doi:10.
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