Autoinflammatory & rare systemic diseases
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Authors' conclusion
We have refined the monodimensional continuum of autoimmune and autoinflammatory diseases as a continuum characterised by both disease inflammation levels and targeted tissues.
Study context
- Population
- Patients with one of 15 autoimmune or autoinflammatory diseases and healthy volunteers443 patients · 71 healthy volunteers
- Outcome
- Immune cell populations characterising autoimmune and autoinflammatory disease clusters (deep immunophenotyping)
Methodological detailsdeep immunophenotyping, 13 flow cytometry panels, unsupervised and supervised analyses
- Deep immunophenotyping
- 13 flow cytometry panels
- Unsupervised and supervised analyses
Main finding
As reported in the abstract
Unsupervised clustering categorised the diseases into five clusters
5
PCA deconvoluted the clustering into two immunological axes
2
Signature of cell populations accurately characterising the five disease clusters
23
Original publication
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types. Ann Rheum Dis. Published 11 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →