Systemic sclerosis & Raynaud's
Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways
Authors' conclusion
Our study confirms the genetic resemblance between susceptibility to and severity of COVID-19 and SSc, revealing a novel common genetic contribution affecting fibrotic and immune pathways.
Study context
- Population
- European-ancestry cohorts from COVID-19 and SSc genomic studies>9.3 million SNPs
- Participants
- 2,597,856 vs 26,679
- Comparison
- COVID-19 vs SSc
- COVID-19n = 2,597,856
- SScn = 26,679
- Outcome
- Shared genetic loci between COVID-19 and SSc
Methodological detailsEuropean-ancestry cohorts, functional annotation, drug repurposing analysis
- European-ancestry cohorts
- Functional annotation
- Drug repurposing analysis
Pooled result
As reported in the abstract
Non-HLA pleiotropic loci
19
Novel associations for both conditions (BMP1 and PPARG)
2
Emerging as new shared loci
12
Antagonistic pleiotropy of IFN signalling: TYK2 P1104A protective for SSc, risk factor for COVID-19; additional novel pleiotropic associations (IRF8 and SENP7)
2
Original publication
Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways. Rheumatology (Oxford). Published 29 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →