Inflammatory myopathies

COVID ‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care Res (Hoboken)Published Case-control study

Authors' conclusion

This comparison did not identify a risk for developing IIM after COVID-19 vaccination.

Study context

Population
US veterans enrolled in the Veterans Health Administration
Participants
89 vs 445
Comparison
Prior COVID-19 vaccination in new-onset idiopathic inflammatory myositis (IIM) cases vs matched controls without IIM
  • Casen = 89
  • Controlsn = 445reference
Outcome
First COVID-19 vaccination before the index date
Methodological detailsmatched 1:5, chart review confirming incident IIM
  • Matched 1:5
  • Chart review confirming incident IIM

Main finding

As reported in the abstract

First COVID-19 vaccination within 30 days before the index date

Odds ratio

1.22

P = 0.643

Case

Adjusted odds ratio

1.12

P = 0.657

Case

Observational data: associations, not effects.

Further findings

First COVID-19 vaccination within 90 days of the index date

OR 0.78 · P = 0.479

OutcomeaORP value
First COVID-19 vaccination within 90 days of the index date0.74P = 0.402

Other comparisons

Multiple other comparisons also failed to identify a statistically significant association between COVID-19 vaccination and IIM

Original publication

COVID ‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans. Arthritis Care Res (Hoboken). Published 13 March 2026. doi:10.1002/acr.70023

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