COVID-19 infection, admission and death and the impact of corticosteroids among people with rare autoimmune rheumatic disease during the second wave of COVID-19 in England: results from the RECORDER Project
Main finding · COVID-19-related deathResult — go to the resultAge-sex-standardized mortality rate ratio 2.76 95% CI 2.63–2.89Authors' conclusion
During the second wave of COVID-19 in England, people with RAIRD had the same risk of COVID-19 infection but a 2.76-fold increased risk of COVID-19-related death compared with the general population, with corticosteroids associated with increased risk.
Study context
- Population
- People with rare autoimmune rheumatic diseases (RAIRD), whole population of England, second wave of COVID-19 (1 August 2020 to 30 April 2021)
- Participants
- 168,330 people
- Exposure
- People with RAIRD vs the general population of England
- RAIRDn = 168,330
- Outcome
- COVID-19 infection and COVID-19-related death (mention of COVID-19 on the death certificate)
- Follow-up
- Up to 30 April 2021
Methodological detailswhole-population, linked national health records, age-standardized and age-sex-standardized comparison with general population
- Whole-population
- Linked national health records
- Age-standardized and age-sex-standardized comparison with general population
Main finding
COVID-19-related death
Age-sex-standardized mortality rate ratio
2.76
95% CI 2.63–2.89
Events by group
RAIRD
0.80%
1342 of 168 330
RAIRDvs General population
age-sex-standardized mortality rate ratio 2.76 (95% CI 2.63–2.89)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | RAIRD | Age-standardized infection rate ratio (95% CI) | |
|---|---|---|---|
| COVID-19 infection (positive PCR test) · up to 30 April 2021 | 5.92% | 0.99 (0.97–1.00) | |
| 0.512Age-standardized infection rate ratio (log scale) |
30-day GC usage and COVID-19-related death
- Dose-dependent relationship between 30-day corticosteroid usage and COVID-19-related death
Deaths due to other causes
- No increase in deaths due to other causes
Original publication
COVID-19 infection, admission and death and the impact of corticosteroids among people with rare autoimmune rheumatic disease during the second wave of COVID-19 in England: results from the RECORDER Project. Rheumatology (Oxford). Published 5 April 2023. doi:10.
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