Correlation between the oxygenation status of extrasynovial tissue in the wrist and disease activity in rheumatoid arthritis: a photoacoustic imaging study
Authors' conclusion
A significant correlation was found to exist between wrist extrasynovial tissue oxygenation and disease activity in patients with RA.
Study context
- Population
- Patients with RA and healthy controls, 2022 to 2023111 RA, 72 healthy controls
- Participants
- 39 / 24 / 48 / 72
- Exposure
- Oxygenation states (hyperoxia, intermediate oxygenation, hypoxia) of wrist extrasynovial tissue in RA vs disease activity; healthy controls
- Hyperoxian = 39
- Intermediate oxygenationn = 24
- Hypoxian = 48
- Healthy controlsn = 72reference
- Outcome
- Correlation of wrist synovial/extrasynovial oxygenation (So2) with disease activity (CDAI)
Methodological detailsphotoacoustic/US (photoacoustic (PA)/US) imaging, dual-wavelength PA imaging, one-way ANOVA and Kruskal-Wallis test with Bonferroni adjustment
- photoacoustic/US (PA/US) imaging
- Dual-wavelength PA imaging
- One-way ANOVA and Kruskal-Wallis test with Bonferroni adjustment
Main finding
As reported in the abstract
Hyperoxia
39
events
Intermediate oxygenation
24
events
Hypoxia
48
events
Observational data: associations, not effects.
Original publication
Correlation between the oxygenation status of extrasynovial tissue in the wrist and disease activity in rheumatoid arthritis: a photoacoustic imaging study. Rheumatology (Oxford). Published 23 January 2024. doi:10.
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