Coronary artery calcium and atherosclerotic cardiovascular disease risk scores in patients with calcium pyrophosphate deposition disease
Authors' conclusion
Coronary atherosclerosis burden by CAC was not significantly different between patients with chondrocalcinosis and matched comparators, though 10-year ASCVD risk scores were higher in the chondrocalcinosis cohort, suggesting that factors beyond coronary artery calcification contribute to the increased CV event rate in patients with CPPD disease.
Study context
- Population
- Patients with an Agatston score in routine care at an academic medical centre, 1991–2022 (mean age 68 years, 53% female)mean age 68 years, 53% female
- Participants
- 756 vs 1,554
- Exposure
- Chondrocalcinosis vs matched comparators without chondrocalcinosis
- Chondrocalcinosisn = 756
- Comparatorsn = 1,554reference
- Outcome
- Agatston (CAC) score, chondrocalcinosis vs matched comparators; primary analysis excluded statin users
Methodological detailssingle-centre (academic medical centre), matched 2:1 on age and sex, primary analysis excluded statin users
- Single-centre (academic medical centre)
- Matched 2:1 on age and sex
- Primary analysis excluded statin users
Main finding
As reported in the abstract
Unadjusted Agatston score
Chondrocalcinosis
359.1
mean · SD 737.9
Comparators
297.1
mean · SD 644.9
P = 0.08
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| High 10-year ASCVD risk scoresSignificantly more common in chondrocalcinosis | P < 0.01 |
Original publication
Coronary artery calcium and atherosclerotic cardiovascular disease risk scores in patients with calcium pyrophosphate deposition disease. Rheumatology (Oxford). Published 12 December 2024. doi:10.
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