Lupus & antiphospholipid syndrome
Contributors to organ damage in childhood lupus: corticosteroid use and disease activity
Authors' conclusion
Disease activity levels (AMS/PGA) and proxy indicators (methylprednisolone exposure, baseline damage) were found to be key predictors of damage accrual.
Study context
- Population
- UK JSLE Cohort Study participants (childhood lupus)
- Participants
- 430 participants
- Outcome
- New damage (damage accrual)
Methodological detailsunivariable and multivariable Prentice-Williams-Peterson models
- Univariable and multivariable Prentice-Williams-Peterson models
Main finding
As reported in the abstract
Predictors of damage, entire cohort
Any methylprednisolone, HR
2.20 (1.33-3.62) (CI)
Time-adjusted mean Physician's Global Assessment (PGA), HR
2.87 (1.48-5.56) (CI)
AMS score, HR
1.13 (1.03-1.24) (CI)
Observational data: associations, not effects.
Further findings
Predictors of damage, low activity subgroup (AMS ≤4)
- Any methylprednisolone, HR
- 2.61 (1.04-6.53) (CI)
- Time-adjusted mean PGA, HR
- 3.41 (1.52-7.76) (CI)
- Both P < 0.05
Predictors of damage, moderate-to-high activity subgroup (AMS >4)
- Any methylprednisolone, HR
- 2.29 (1.31-4.00) (CI)
- Time-adjusted mean PGA, HR
- 2.66 (1.20-5.87) (CI)
- AMS score, HR
- 1.15 (1.03-1.29) (CI)
- All P < 0.05
Baseline organ damage as predictor of damage accrual, minimal disease activity (AMS ≤2) and no CS subgroups
- Minimal disease activity subgroup, HR
- 1.33 (1.78-8.08) (CI)
- No CSs subgroup, HR
- 3.64 (1.83-7.24) (CI)
- Both P < 0.005
Original publication
Contributors to organ damage in childhood lupus: corticosteroid use and disease activity. Rheumatology (Oxford). Published 22 October 2024. doi:10.
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