Systemic sclerosis & Raynaud's
Clinically relevant differences between primary Raynaud's phenomenon and secondary to connective tissue disease
Authors' conclusion
There are clinically relevant differences between PRP and SRP concerning the multifaceted lived patient experience of RP. Neurosensory symptoms are more common in PRP. Patients with SRP are older and present with more colour changes, overrepresented by cyanosis, and with less complete resolution of symptoms between attacks.
Study context
- Population
- Respondents with self-reported raynaud's phenomenon (RP) completing the PASRAP online surveycompleted PASRAP
- Participants
- 1,229 respondents
- Exposure
- Primary RP vs RP secondary to connective tissue disease
- Primary RP (PRP)n = 218
- Secondary RP (SRP)n = 1,011
- Outcome
- Patient-reported RP experience: age, attack symptoms, symptom control
Methodological detailsonline patient survey, voluntary, anonymous responses
- Online patient survey
- Voluntary, anonymous responses
Main finding
As reported in the abstract
- Important differences in triggers, number and seasonal variation of RP attacks
Observational data: associations, not effects.
Further findings
Age (years)
P < 0.0001
Cyanotic colour changes during attacks
P = 0.0089
Pain during attacks
P < 0.0001
Numbness during attacks
P = 0.0016
Stinging/throbbing during attacks
P < 0.0001
Tingling during attacks
P = 0.0345
Symptoms adequately controlled by current medication(s) · only half of respondents adequately controlled
P = 0.0084
Original publication
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