Clinical significance of a self-reported familial occurrence of rheumatoid arthritis among patients with recent-onset arthritis: data from the ESPOIR cohort
Authors' conclusion
In the specific context of early arthritis, a self-reported familial occurrence of RA is associated with the future decision to initiate a targeted DMARD.
Study context
- Population
- Patients with recent-onset arthritis (≥2 swollen joints for >6 weeks and <6 months, no other diagnosis than rheumatoid arthritis (RA), no previous GC or DMARD exposure) included 2002–2005 in the ESPOIR cohort
- Exposure
- Self-reported familial occurrence of RA vs no familial occurrence
- Familial RAn = 115
- Outcome
- Initiation of a targeted DMARD over time
Methodological detailsearly arthritis ESPOIR cohort, logistic and Cox regression models
- Early arthritis ESPOIR cohort
- Logistic and Cox regression models
Main finding
As reported in the abstract
Familial RA vs No familial RAHazard ratio (95% CI)P value
Unadjusted
1.57(1.1–2.21)
P = 0.01Adjusted
1.51(1.06–2.15)
P = 0.02Observational data: associations, not effects.
Further findings
Extra-articular manifestations at baseline
P = 0.01
Severe extra-articular manifestations at baseline
p 0.01
Original publication
Clinical significance of a self-reported familial occurrence of rheumatoid arthritis among patients with recent-onset arthritis: data from the ESPOIR cohort. Clin Exp Rheumatol. Published 4 March 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →