Systemic sclerosis & Raynaud's
Clinical significance of inflammation-coagulation-autoantibody triad in systemic sclerosis-associated interstitial lung disease: a retrospective study
Authors' conclusion
NLR, PT, and anti-SCL-70 antibody together form a triad of independent associated factors for SSc-ILD, demonstrating substantial discriminatory potential when considered as a composite indicator.
Study context
- Population
- Patients with systemic sclerosis (SSc)
- Participants
- 177 patients
- Exposure
- SSc-ILD vs SSc without interstitial lung disease (ILD)
- SSc-ILDn = 116
- Without ILDn = 61reference
- Outcome
- Independent and combined value of inflammatory markers, coagulation parameters and autoantibodies for the presence of SSc-ILD
Methodological detailsmultivariate logistic regression, ROC analysis with DeLong test
- Multivariate logistic regression
- ROC analysis with DeLong test
Main finding
As reported in the abstract
Discrimination of SSc-ILD by combined model (NLR, PT, anti-SCL-70)
- Combined model AUC
- 0.879 (95% CI 0.828-0.930)
- Combined model AUC greater than any individual marker
- P < 0.001
- Combined model sensitivity
- 82.6%
- Combined model specificity
- 85.0%
Observational data: associations, not effects.
Further findings
Clinical features
- Incidence of dcSSc, Raynaud's phenomenon and digestive involvement significantly higher in SSc-ILD
Original publication
Clinical significance of inflammation-coagulation-autoantibody triad in systemic sclerosis-associated interstitial lung disease: a retrospective study. Arthritis Res Ther. Published 12 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →