Clinical heterogeneity and prognostic factors of anti-synthetase syndrome: a multi-centred retrospective cohort study
Authors' conclusion
In view of the heterogeneity of clinical presentation of ASyS, a high index of suspicion and early checking of specific autoantibodies might help prompt diagnosis of ASyS and detection of related complications.
Study context
- Population
- Patients with anti-synthetase syndrome (ASyS) fulfilling Connor's or Solomon's criteria; electronic health records reviewed until October 2022median follow-up 4 years
- Participants
- 205 patients
- Exposure
- Anti-Jo1 vs Anti-PL7 vs Anti-EJ vs Anti-PL12 vs Anti-OJ
- Outcome
- Clinical characteristics, complications and factors associated with survival
Methodological detailsmulticentre, longitudinal, multivariate Cox regression
- Multicentre
- Longitudinal
- Multivariate Cox regression
Main finding
As reported in the abstract
- Initial presentation: myositis
- 56.1%
- Initial presentation: arthritis
- 54.6%
- Initial presentation: Interstitial lung disease (ILD)
- 54.1%
- Died (pulmonary diseases, ILD or pneumonia, the major causes)
- 15.6%
Observational data: associations, not effects.
Further findings
Time from symptom onset to diagnosis
- Significantly longer for non-anti-Jo1 patients (median 5 vs 3 months)
Antibody-specific features
- Anti-OJ: malignancy
- 28.6%
- Anti-Jo1: significantly higher muscle enzyme levels and more arthritis
- Anti-EJ: all developed ILD on follow-up
Original publication
Clinical heterogeneity and prognostic factors of anti-synthetase syndrome: a multi-centred retrospective cohort study. Rheumatology (Oxford). Published 14 December 2023. doi:10.
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