Clinical characteristics of rheumatoid arthritis patients with interstitial lung disease: baseline data of a single-center prospective cohort
Authors' conclusion
Higher age at RA onset, smoking history, and higher BMI were associated with the presence of ILD among RA patients. Oral glucocorticoids were more frequently used whereas methotrexate was less likely to be used in RA-ILD patients.
Study context
- Population
- Rheumatoid arthritis (RA) patients with and without interstitial lung disease (ILD), single-centre cohort, enrolment May 2017 to March 2021
- Participants
- 148 vs 410
- Exposure
- RA with ILD vs RA without ILD
- RA-ILDn = 148
- RA-non ILDn = 410reference
- Outcome
- Factors associated with ILD in RA patients
Methodological detailssingle-centre, baseline data, multivariable logistic regression
- Single-centre
- Baseline data
- Multivariable logistic regression
Main finding
As reported in the abstract
Factors associated with ILD in RA (multivariable logistic regression)
Odds ratio (95% CI)
Higher age at RA onset
1.056(1.021–1.091)
Higher BMI
1.65(1.036–2.629)
Smoking history
2.484(1.071–5.764)
Oral GC use
3.562(2.160–5.874)
MTX useless likely to be associated with ILD
0.253(0.155–0.412)
Observational data: associations, not effects.
Further findings
Age
P < 0.001
Male sex
P < 0.001
Late-onset RA (age ≥ 60 years)
P < 0.001
Original publication
Clinical characteristics of rheumatoid arthritis patients with interstitial lung disease: baseline data of a single-center prospective cohort. Arthritis Res Ther. Published 17 March 2023. doi:10.
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