Clinical characteristics and risk factors of coronary artery lesions in chinese pediatric Takayasu arteritis patients: a retrospective study
Authors' conclusion
This study showed that the occurrence of CAL in pediatric TAK patients has a relatively more rapid clinical course, and a stronger inflammatory state at the time of diagnosis. The earlier the age of TAK onset and without RAS are more likely to cause CAL.
Study context
- Population
- Chinese pediatric TAK patients at one centre
- Participants
- 66 patients
- Exposure
- Pediatric TAK with CAL vs without CAL
- Outcome
- Incidence of and risk factors for CALs in pediatric TAK
Methodological detailssingle-centre, multivariate logistic regression, survival analysis
- Single-centre
- Multivariate logistic regression
- Survival analysis
Main finding
As reported in the abstract
Incidence of CALs
Incidence of accompanying coronary artery lesions (CALs)
39.4%
Observational data: associations, not effects.
Further findings
Risk factors for CAL (multivariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Age of TAK onset | 0.9835 (0.9710–0.9946) | P = 0.006 | |
| RAS | 0.1901 (0.0386–0.7503) | P = 0.03 | |
| 0.050.21520Odds ratio (log scale) |
- Onset within 36 months (CAL group)
- 73.1% · 19 events
Clinical and laboratory differences, CAL vs without CAL
- Lower age of onset and symptom onset to diagnosis with CAL
- P < 0.005
- Higher CRP, WBC, PLT, TNF-α and IL-2R levels with CAL
- P < 0.05
- Lower HGB with CAL
- P = 0.01
- Lower rate of RAS with CAL
- P = 0.009
Survival after regular treatment
- No significant difference in survival rates between the two groups
Original publication
Clinical characteristics and risk factors of coronary artery lesions in chinese pediatric Takayasu arteritis patients: a retrospective study. Pediatr Rheumatol Online J. Published 28 April 2023. doi:10.
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