Clinical and ultrasound features of difficult-to-treat rheumatoid arthritis: A multicenter rheumatoid arthritis (RA) ultrasound cohort study
Authors' conclusion
Patients with D2T RA had high clinical and ultrasound activity and poor responses to treatment with b/tsDMARDs. CTLA4-Ig was associated with a good response at 12 months in D2T RA patients.
Study context
- Population
- Japanese patients with RA treated with b/tsDMARDs
- Participants
- 307 patients
- Exposure
- Difficult-to-treat (D2T) RA vs non-D2T RA
- D2T RAn = 43
- Non-D2T RAn = 264reference
- Outcome
- Good response (b/tsDMARD continuation and CDAI ≤ 10) in D2T RA
- Follow-up
- 12 months
Methodological detailsRA ultrasound observational cohort, inverse probability weighting with propensity score
- RA ultrasound observational cohort
- Inverse probability weighting with propensity score
Main finding
As reported in the abstract
Good response in D2T RA
D2T RA
20
events
Observational data: associations, not effects.
Further findings
Baseline characteristics, D2T RA vs non-D2T RA · treatment initiation
- Grey-scale (GS) score, disease duration and CDAI significantly higher in D2T RA
- Power Doppler (PD) score not significantly different between groups
Original publication
Clinical and ultrasound features of difficult-to-treat rheumatoid arthritis: A multicenter RA ultrasound cohort study. Scand J Rheumatol. Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →