Decline in Incidence of Extra‐Articular Manifestations of Rheumatoid Arthritis: A Population‐Based Cohort Study
Authors' conclusion
The incidence of ExRAs has decreased over time. Mortality remains increased in patients with ExRAs.
Study context
- Population
- All adult patients with incident rheumatoid arthritis (RA) from 1985 through 2014 meeting the 1987 ACR criteria
- Participants
- 907 patients
- Exposure
- RA incident 1985 to 1999 vs RA incident 2000 to 2014
- 1985 to 1999n = 296reference
- 2000 to 2014n = 611
- Outcome
- Cumulative incidence of any extra-articular manifestation of RA (ExRA)
- Follow-up
- 10 years
Methodological detailsmanual chart review, Cox proportional hazard models
- Manual chart review
- Cox proportional hazard models
Main finding
As reported in the abstract
10-year cumulative incidence of any ExRA
- 1985 to 1999 vs 2000 to 2014: P < 0.001
- Earlier cohort = 1985 to 1999; later cohort = 2000 to 2014
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| 10-year cumulative incidence of subcutaneous rheumatoid nodules · significant decline | P < 0.001 |
| 10-year cumulative incidence of nonsevere ExRAs · significant decline | P = 0.001 |
- 10-year cumulative incidence of subcutaneous rheumatoid nodules: earlier cohort = 1985 to 1999; later cohort = 2000 to 2014
- 10-year cumulative incidence of nonsevere ExRAs: earlier cohort = 1985 to 1999; later cohort = 2000 to 2014
Risk factors for any ExRA
- Rheumatoid factor positivity, HR
- 2.02 (95% CI 1.43-2.86)
- Current smoking, HR
- 1.61 (95% CI 1.10-2.34)
Mortality in patients with ExRAs
- Nonsevere ExRAs, HR
- 1.83 (95% CI 1.18-2.85)
- Severe ExRAs, HR
- 3.05 (95% CI 1.44-6.49)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Decline in Incidence of Extra‐Articular Manifestations of Rheumatoid Arthritis: A Population‐Based Cohort Study. Arthritis Care Res (Hoboken). Published 10 December 2023. doi:10.
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