Spondyloarthritis & psoriatic arthritis
Clinical and ultrasonographic predictors of disease activity after TNF-α inhibitor spacing in patients with psoriatic arthritis
Authors' conclusion
In this study, anti-TNF-α spacing proved to be feasible in most of the PsA patients in a stable MDA. The only factor predictive of persistence of remission was a very low clinical disease activity at baseline.
Study context
- Population
- Consecutive adult patients with PsA taking TNFi and in stable Minimal Disease Activity (MDA) who accepted dose reduction by doubling the administration intervalevaluable
- Participants
- 72 patients
- Exposure
- Patients maintaining MDA vs patients with disease flare after TNFi spacing
- Maintained MDAn = 55
- Relapsen = 17
- Outcome
- Factors associated with persistence of MDA after anti-TNF-α spacing
- Follow-up
- 12 months
Methodological detailsobservational, multicentre, 12-month
- Observational
- Multicentre
- 12-month
Main finding
As reported in the abstract
Persistence of MDA after anti-TNF-α spacing
Observational data: associations, not effects.
Original publication
Clinical and ultrasonographic predictors of disease activity after TNF-α inhibitor spacing in patients with psoriatic arthritis. Joint Bone Spine. Published 25 February 2025. doi:10.
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