Characterizing the lavage and serum cytokine profiles of interstitial pneumonia with autoimmune features and their implications for progressive fibrosis
Authors' conclusion
PF-IPAF phenotype exhibits similar inflammatory cytokine profiles to IPF. Cytokine CCL2 and CXCL12, and LYM% in BALF serve as potential biomarkers for predicting the PF phenotype in IPAF patients.
Study context
- Population
- Patients with Interstitial Pneumonia with Autoimmune Features (IPAF) or Idiopathic Pulmonary Fibrosis (IPF) diagnosed at the First Affiliated Hospital of Guangzhou Medical University, July 2020 to June 2021
- Participants
- 51 vs 15
- Exposure
- IPAF vs IPF; IPAF subtypes by bronchoalveolar lavage fluid (BALF) cytokine profile
- IPAFn = 51
- IPFn = 15reference
- Outcome
- Development of progressive fibrosis (PF) phenotype in IPAF; 39 cytokines in paired BALF and serum at enrolment
- Follow-up
- 1 year
Methodological detailssingle-centre, 1-year follow-up, principal component analysis, cluster analysis
- Single-centre
- 1-year follow-up
- Principal component analysis
- Cluster analysis
Main finding
As reported in the abstract
PF phenotype in IPAF: cytokine profiles and predictors
- PF-IPAF patients sharing overlapped BALF cytokine profiles with IPF (principal component analysis (PCA))
- 81.25%
- IPAF subtype 2 (higher CCL2 and CXCL12, lower BALF LYM%): higher risk of progressive fibrosis (PF) phenotype within 1 year
- P = 0.048
- Elevated BALF CCL2 (>299.16 pg/ml): significantly higher risk of PF phenotype within 1 year
- P = 0.009
- Elevated BALF CXCL12 (>660.115 pg/ml): significantly higher risk of PF phenotype within 1 year
- P = 0.001
Observational data: associations, not effects.
Original publication
Characterizing the lavage and serum cytokine profiles of interstitial pneumonia with autoimmune features and their implications for progressive fibrosis. Rheumatology (Oxford). Published 22 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →