Vasculitis & polymyalgia rheumatica
Characteristics and clustering analysis of peripheral-blood lymphocyte subsets in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
Authors' conclusion
The counts of lymphocyte are lower in patients with active AAV than HCs. Decreased lymphocyte subsets may serve as a biomarker for assessing disease severity and predict poor outcome in AAV patients.
Study context
- Population
- Patients with ANCA-associated vasculitis (active or in induced remission) and healthy controls
- Participants
- 247 / 70 / 252
- Exposure
- Active AAV and AAV in induced remission vs healthy controls (HCs)
- Active AAVn = 247
- Induced remissionn = 70
- HCsn = 252reference
- Outcome
- Clusters of peripheral-blood lymphocyte subsets and their correlation with clinical characteristics
Methodological detailsprincipal component analysis, cluster analysis
- Principal component analysis
- Cluster analysis
Main finding
As reported in the abstract
Peripheral-blood lymphocyte subsets
- All lymphocyte subsets except B cells negatively correlated with BVAS in AAV
- p<0.01
- Percentage and absolute number of B cells markedly decreased in induced remission
- p<0.0001
- Cluster analysis classified patients into three distinctive subgroups; cluster 2 had highest WBC count, serum albumin, monocyte count and eGFR, and lowest serum creatinine and ESR
- p<0.05
Observational data: associations, not effects.
Original publication
Characteristics and clustering analysis of peripheral-blood lymphocyte subsets in patients with ANCA-associated vasculitis. Clin Exp Rheumatol. Published 21 November 2024. doi:10.
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