Cell‐Mediated Cytotoxicity in Lyme Arthritis
Authors' conclusion
We propose that CD8+ T cell-mediated cytotoxicity, CD4+ T cell help, autoantibodies to vascular antigens, and complement deposition may each have a role in microvasculature damage in post-antibiotic LA.
Study context
- Population
- Patients with antibiotic-responsive or post-antibiotic Lyme arthritis; PBMC and SFMC samples, post-antibiotic synovial tissue
- Participants
- 22 vs 14
- Comparison
- Post-antibiotic Lyme arthritis (LA) vs antibiotic-responsive LA
- Post-antibiotic LAn = 22
- Antibiotic-responsive LAn = 14reference
- Outcome
- Percentages of CD8+ T cells and double-negative (primarily γδ) T cells in SFMC and PBMC samples
Methodological detailsflow cytometry, intracellular cytokine staining, immunohistochemistry
- Flow cytometry
- Intracellular cytokine staining
- Immunohistochemistry
Main finding
As reported in the abstract
Patients with microvascular damage and autoantibodies to vascular-associated antigens
2
Complement (C5b-9) deposition on obliterated vessels, in the patient with apparently active cytotoxicity
1
Original publication
Cell‐Mediated Cytotoxicity in Lyme Arthritis. Arthritis Rheumatol. Published 20 March 2023. doi:10.
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