Criteria for Hyperinflammation Developing in COVID‐19: Analysis of 2 Cohorts From Different Periods of the Pandemic
Authors' conclusion
The use of the 12-item criteria for HIC can better define patients with HIC with reasonable sensitivity and specificity and enables an earlier treatment start.
Study context
- Population
- Hospitalized patients with symptomatic COVID-19 in Turkey2 cohorts
- Participants
- 685 vs 156
- Comparison
- 12-item criteria for COVID-19-associated hyperinflammation (HIC) vs expert panel diagnosis
- Discoveryn = 685
- Replicationn = 156
- Outcome
- Sensitivity and specificity of 12-item criteria for identification of HIC
Methodological detailsdiscovery and replication cohorts, expert panel diagnosis
- Discovery and replication cohorts
- Expert panel diagnosis
Performance
As reported in the abstract
12-item HIC criteria, score of 35, identification of HIC (discovery cohort)
Sensitivity, score of 35
85.3%
Specificity, score of 35
81.7%
Further findings
Events
| Outcome | Discovery | Replication |
|---|---|---|
| Patients receiving treatment for HI | 150 | 61 |
Mortality
- Hyperinflammation (HI) patients, discovery cohort
- 23.3%
- Patients without HI, discovery cohort
- 3.7%
- Overall replication cohort
- 10.3%
Original publication
Criteria for Hyperinflammation Developing in COVID‐19: Analysis of 2 Cohorts From Different Periods of the Pandemic. Arthritis Rheumatol. Published 20 March 2023. doi:10.
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