Vasculitis & polymyalgia rheumatica
Causal relationship between 731 immune cell immunophenotypes and giant cell arteritis: a Mendelian randomisation study
Authors' conclusion
The study advances our understanding of the immunological underpinnings of GCA, suggesting that specific immune cells significantly influence the disease's development.
Study context
- Population
- Genome-wide association studies (GWAS) data of 3,757 European individuals
- Participants
- 3,757 European individuals
- Comparison
- Genetically predicted immune cell traits and giant cell arteritis (GCA), in both directions
- Outcome
- GCA (forward MR)
Methodological detailsbilateral (forward and reverse) Mendelian randomisation (MR), inverse-variance weighted (IVW) method, sensitivity analyses
- Bilateral (forward and reverse) MR
- IVW method
- Sensitivity analyses
Main finding
As reported in the abstract
- Absolute count of monocytic myeloid-derived suppressor cells: protective effect
- HLA DR on CD14+ CD16- monocytes: increased risk
- HLA DR on CD14+ monocytes: increased risk
- Three immune traits with significant associations
Further findings
Reverse MR (GCA on immune traits)
- No statistically significant results
Sensitivity analyses
- Results consistent with the main findings
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Causal relationship between 731 immune cell immunophenotypes and giant cell arteritis: a Mendelian randomisation study. Clin Exp Rheumatol. Published 13 March 2024. doi:10.
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