Lupus & antiphospholipid syndrome
CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus
Authors' conclusion
CASTOR1 plays a regulatory role in humoral immunity and may contribute to the pathogenesis of autoimmune diseases such as SLE, representing a potential therapeutic target.
Study context
- Population
- Human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) (Immune Cell Gene Expression Atlas, University of Tokyo); Castor1-deficient and B cell-specific Castor1-deficient mice
- Participants
- 136 SLE patients
- Outcome
- Correlation of CASTOR1 expression in plasmablasts with SLEDAI-2K in patients with SLE
Methodological detailshuman B cell transcriptome analysis, Castor1-deficient and B cell-specific Castor1-deficient mice
- Human B cell transcriptome analysis
- Castor1-deficient and B cell-specific Castor1-deficient mice
Main finding
As reported in the abstract
CASTOR1 expression in plasmablasts inversely correlated with SLEDAI-2K (r)
r = −0.32
P = 0.00031
Original publication
CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus. Arthritis Rheumatol. Published 4 September 2026. doi:10.
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