Carotid-femoral pulse wave velocity improves cardiovascular risk prediction beyond SCORE2 in autoimmune rheumatic diseases: a 7-year follow-up study
Main finding · Prediction of CVEsResult — go to the resultHazard ratio (age-adjusted Cox) 1.19 95% CI 1.00–1.39Authors' conclusion
cfPWV is an independent predictor of future CVEs in patients with ARDs and outperforms SCORE2 in long-term risk prediction.
Study context
- Population
- Patients with RA, SSc and SpA with clinically indicated baseline non-invasive carotid-femoral pulse wave velocity (cfPWV) assessment 2012–2017 because of at least one additional CV risk factor
- Participants
- 143 patients20 cardiovascular events (CVEs)
- Exposure
- cfPWV vs SCORE2 for prediction of cardiovascular events
- Outcome
- Incident cardiovascular events (prognostic value of cfPWV vs SCORE2)
- Follow-up
- median 7-year follow-up
Methodological detailsmedian 7-year follow-up, Cox proportional hazards models, ROC analysis
- Median 7-year follow-up
- Cox proportional hazards models
- ROC analysis
Main finding
Prediction of CVEs
Hazard ratio (age-adjusted Cox)
1.19
95% CI 1.00–1.39
P = 0.047
By group
cfPWV
HR (age-adjusted Cox) 1.19 (95% CI 1.00–1.39); P = 0.047
As reported in the abstract
- cfPWV AUC
- 0.84 (95% CI 0.73 to 0.93); sensitivity 0.87, specificity 0.73
- SCORE2 AUC
- 0.56 (95% CI 0.41 to 0.72); sensitivity 0.60, specificity 0.69
Observational data: associations, not effects.
Further findings
Baseline SCORE2 · did not differ
P = 0.35
Correlates of cfPWV · baseline
- Age
- P < 0.001
- Mean arterial pressure
- P = 0.013
- CRP
- P = 0.011
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Carotid-femoral pulse wave velocity improves cardiovascular risk prediction beyond SCORE2 in autoimmune rheumatic diseases: a 7-year follow-up study. RMD Open. Published 16 June 2026. doi:10.
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